One Piece Bounty Rush has a team of four players competing against another team of four players in real-time, with each battlefield being based on a location within the One Piece series. The winner is whichever team has the most coins at the end of a battle. Players can enhance a character’s level by collecting in-game items from either the story mode or a battlefield.

Each team has to place their own flag on treasure to claim it. The three character types within a team are Runner, Attacker, or Defender. The runner grabs points, the attacker fights enemies, and the defender moves enemies out of the way. There are a variety of characters to choose from and each character has their own attacks. The attacks include a basic combo and special skills. When using a basic combo, the player has to attack whatever character is closest. Every point from claiming treasure gives the player a small bonus after the battle. When a basic combo is finished, the enemy is knocked down, but they have the ability to not be harmed while getting back up.